WebbHere, we define that the Prrx1 transcription factor is critical for tuning CAF activation, allowing a dynamic switch between a dormant and an activated state. This work shows … Webb17 maj 2024 · In axolotls, the Prrx1-descendants from the interstitium and dermis enter the blastema and converge to a common multipotent progenitor type that can regenerate all CT subtypes including skeleton, tendons, ligaments, interstitium, and dermis (Gerber et al., 2024).To ask whether frog CT subpopulations follow a similar program, we performed …
MiR-124 Radiosensitizes Human Colorectal Cancer Cells by Targeting PRRX1
Webb11 dec. 2012 · Indeed, Prrx1-expressing MDCK cells adopted a mesenchymal morphology concomitant with loss of E-cadherin expression and gain of vimentin (Figure 2 A). In cultured wound-healing assays, these MDCK-Prrx1 cells healed the wound much faster than control cells (Figure 2 B) and they could migrate through collagen gels (Figure 2 C). WebbIn 2012, Ocana et al first found that overexpression of PRRX1 could promote EMT in cancer cells. 8 Recent studies have reported that PRRX1 is involved in the metastasis of many … optiscout handbuch
Probes for CTNNB1 In Situ Hybridization, RNA-ISH ACDBio
Webb8 jan. 2024 · Resident Prrx1 lineage stromal cells promote T cell survival via IL6 in the spleen. (A) Location and characterization of Prrx1 lineage cells of the spleen of 8-week-old Prrx1-Cre;tdTomato mice.Spleen sections were stained with anti-CD31 and anti-gp38 antibodies, respectively. (B–G) Specifically killing Prrx1 lineage cells resulted in … Webb25 juli 2024 · Using different Cre drivers in the adipocyte lineage, we initiated in vivo tumorigenesis by expressing FUS-CHOP in Prrx1 + mesenchymal progenitor cells. In contrast, expression of FUS-CHOP in more differentiated cells does not form tumors in vivo , and early expression of the oncoprotein during embryogenesis is lethal. Webb24 aug. 2024 · 1. Introduction. A key feature of tissue morphogenesis is the ability of cells to rapidly and reversibly change their phenotype. This is termed cell plasticity and is exemplified by the shift of polarized epithelial cells to an unpolarized migratory mesenchymal state, and vice versa ().This epithelial–mesenchymal plasticity (EMP) is … optisches tuning