WebMar 8, 2024 · Flycatcher1 (FLYC1) is a candidate mechanosensitive channel involved in Venus flytrap touch-induced prey capture. Here, the authors report structural and functional details of FLYC1, with insights ... WebFeb 17, 2024 · FLYC1 is a larger protein and its sequence diverges from previously studied MscS homologs, suggesting it has unique structural features that contribute to its …
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We expressed a C-terminal EGFP fusion construct of full-length FLYC1 protein in mammalian cells, purified the protein in detergent, and prepared grids for cryo-EM analysis. A subset of particles identified by 3D classification yielded a 2.8 Å resolution reconstruction without symmetry applied. In this … See more The central pore axis of FLYC1 is lined by TM6 in the TMD and by the cytoplasmic cage in the cytosol. The narrowest constriction in the … See more While TM6 and the cytoplasmic cage, both close to the central axis, appear to be stabilized by interdomain and intersubunit contacts, the remainder of the FLYC1 molecule has minimal packing within and between subunits, … See more Which parts of the structure contribute to ion selectivity and conduction properties of FLYC1? Charge reversal mutations of the only two pore-facing … See more WebJun 30, 2024 · FLYC1 is larger and its sequence diverges from previously studied MscS homologs, suggesting it has unique structural features that contribute to its function. … earths marvel
Stretch-activated ion channels identified in the touch
WebFLYC1 mRNA localization in Venus flytrap trigger hairs. (A) Toluidine blue-stained longitudinal section through the base of a trigger hair. Elongated sensory cells are visible at the indentation... WebHe discovered a new gene that he and his colleagues named FLYCATCHER1, or FLYC1 for short. SPREADING SCIENCE Procko is not only passionate about his own research … WebFeb 17, 2024 · FLYC1 is a larger protein and its sequence diverges from previously studied MscS homologs, suggesting it has unique structural features that contribute to its function. Here, we characterize FLYC1 by cryo-electron microscopy, molecular dynamics simulations, and electrophysiology. earthsmedicines skincare