WebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 did not totally abrogate the DNA-binding … WebCCCTC-binding factor (CTCF) is a zinc-finger protein, serving an important part in the genome architecture as well as some biochemical processes. Over 70,000 CTCF binding …
The Myc-associated zinc finger protein (MAZ) works …
Web1 day ago · This revealed profoundly different behaviors among proteins engaged in common processes, with cohesin and CTCF among the most extensively investigated proteins. Although both are involved in loop and TAD formation, cohesin and CTCF have distinct kinetics and different effects on chromatin mobility. ... CTCF interacts through its … WebThe CTCF protein The organization of the chicken and human CTCF loci is shown in Fig. 1a,b. The exon–intron organization is identical in mice and humans, as are the sequences of the entire promoter regions, 5 ′- and 3′-untranslated regions (UTRs) and each splice donor–acceptor site(G.N. Filipova et al., unpublished). Compared with the ... graphql calculated fields
Review TRENDS in Genetics Vol.17 No.9 September 2001 …
WebBACKGROUND: CTCF (CCCTC-binding factor) is an evolutionarily conserved zinc finger protein involved in diverse functions ranging from negative regulation of MYC, to chromatin insulation of the ... WebAug 31, 2024 · CTCF zinc-finger recognition modes were examined at several DNA sites with finger-truncated mutant proteins, which revealed the DNA binding effective regions comprising different sets of consecutive fingers20, 21, 22. The contribution of the internal fingers in the effective region was nevertheless unknown due to the restriction of the … WebThe ubiquitously expressed CCCTC-binding factor (CTCF) is a highly conserved transcription factor carrying 11 zinc finger domains involved in multiple DNA sequence-specific recognition [1,2,3].Combinatorial use of zinc fingers is also responsible for CTCF pleiotropic functions including transcriptional activation/repression, insulator activity, and … chi steam irons on sale