Camptothecin hl-60

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Identification of novel topoisomerase II alpha inhibitors by virtual ...

WebJun 1, 2000 · Camptothecin (50 mM), a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I, was used as a positive control (King et al., 2000). ... Internalization of Bacillus intermedius... WebAug 1, 1993 · Since apoptosis has been associated with potential involvement of intracellular signaling linked to the Ca 2+ /calmodulin and protein kinase C transduction … ctown peekskill ny

Camptothecin - an overview ScienceDirect Topics

WebMay 1, 2000 · The promyelocytic HL-60 cell lines have been used extensively to study drug-induced apoptosis, particularly with camptothecin (Palissot et al., 1996; Shimizu and Pommier, 1997; King et al., 2000 ... WebCamptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the 1960s.67 … WebOct 21, 2024 · New 2,3-disubstituted thieno[2,3-d]pyrimidin-4(3H)-ones were synthesized via a one-pot reaction from 2H-thieno[2,3-d] [1,3]oxazine-2,4(1H)-diones, aromatic aldehydes, and benzylamine or 4-hydroxylbezylamine. The obtained compounds were tested in vitro for cancer cell growth inhibition. Compound 19 can inhibit all four types of tested cancer … earth shedding its skin

Apoptosis and Its Modulation in Human Promyelocytic HL …

Effects of recombinant human PLD2 on proliferation and apoptosis of HL ...

WebOct 1, 2003 · (A) HL-60 cells were treated with various doses of camptothecin, a DNA topoisomerase I inhibitor, for 20 hours. (B) H-7 cells were deprived of IL-3 for the indicated times. (Upper panels) Proteins were extracted and subjected to SDS-PAGE and Western blotting with anti-Bax antibody. WebHL-60 cells exposed to okadaic acid and camptothecin underwent morphological and biochemical changes typical of apoptosis, including internucleosomal DNA fragmentation and PAI-2 cleavage. earths healing north locationWebOct 1, 2003 · (A) HL-60 cells were treated with 2 μM camptothecin only or in the presence of 20 μM calpeptin (calpain inhibitor), or 20 μM cathepsin inhibitor I (CI) or 20 μM ALLM (inhibits calpain and cathepsin) for the indicated times. (B) HL-60 cells were treated with 20 μM cisplatin, or 50 μM etoposide or 0.5 μg/mL adriamycin alone for 20 hours or ... earth s healing south

"Web14808-60-7 Wt. % 60 - 100 1 - 5 This product is a hazardous chemical as defined by the OSHA Hazard Communication Standard, 29 CFR 1910.1200. Gypsum (calcium sulfate) … " - Camptothecin hl-60

Camptothecin hl-60

DNA Damage and Cell Killing by Camptothecin and Its …

WebJul 26, 2024 · CP6 displayed potent and comparable cytotoxicity. Interestingly, CP6 exhibited weak cytotoxicity against the normal cell line HUVEC and HL-7702 with a higher IC 50 (22.5 μM) and (18.5 μM). CP6 show minimal cytotoxicity against the human cervix adenocarcinoma cancer cell line HeLa with an IC 50 of 5.5 μM. WebJun 13, 2024 · Camptothecin is an anticancer molecule which acts by targeting the human deoxyribonucleic acid topoisomerase I (Topo-I). It inhibits the enzyme by blocking the re-joining step of the cleavage reaction of Topo-I, which causes accumulation of a covalent reaction intermediate.

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WebJan 15, 2024 · In summary, 12 novel biotinylated camptothecin derivatives were designed, synthesized, and evaluated for anticancer activities against a panel of five human cancer … WebThis potent antioxidant is a cytoprotectant in several experimental models. However, its neuroprotective activities are scarcely available, especially in the hippocampal region associated with...

WebThere have been some conflicting results concerning whether annexin V binds to camptothecin (CAM)-treated HL-60 cells, a commonly used model for apoptosis. We investigated the effects of culturing HL-60 cells for up to 8 h with a range of CAM concentrations. METHODS We used flow cytometry to measure cellular light scatter, … WebNov 5, 2015 · The effect of vincristine, cisplatin or 10-hydroxy camptothecin on inducing apoptosis of HL-60 cells co-cultured with the MS-5 cell layer within 48 h was tested with/without E5.

WebCamptothecin [47, 48]. binds non-covalently with topoisomerase-I and suppresses their catalytic activity, thus show- Vinblastine and its derivatives have been used ing anti-cancer properties. ... (HL-60, MCF-7) with IC50 value Due to the large diversity of endophytic fungi, (5.8, 20.15 μM) [92]. Incarxanthone B, a novel various novel cytotoxic ... WebAug 15, 2024 · The IC 50 values on the HL60 cells are comparable to SN38 and 9-N - (2′-hydroxyethyl)methyl substituted compound 2b. Table 1. IC 50 values of Irinotecan (1c), SN38 (1d) and SN38 derivatives 2a-j. nontoxic - lack of cell viability decrease/toxicity in the studied compound concentration range.

WebCamptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata that was identified in an anticancer drug discovery screen in the 1960s. 68 …

Web周珏，卢林明，张根葆(皖南医学院 1.病理解剖学教研室;2.病理生理学教研室;3.蛇毒研究所，安徽芜湖 241002)蛇毒具有广泛的生 ctown readingWebFeb 1, 2008 · In the present study, we investigated the role of recombinant human phospholipase D2 (rhPLD2) on proliferation and apoptosis in human leukemia HL‐60 cells which induced by camptothecin. Our research demonstrated that various concentrations of rhPLD2 inhibit the growth of HL‐60 cells in a dose‐dependent manner, and rhPLD2 plus … earths healing south hoursWebFounded. 1932. Founder. Harold L. Green. Defunct. 1990s. Fate. Closed as part of parent company ( McCrory Stores) bankruptcy in 2001. H. L. Green was a five and dime store … earths healing north hoursWebAug 1, 1999 · HL-60 human promyelocytic leukemia cells were cultured in RPMI 1640 supplemented with 10% fetal bovine serum. For induction of apoptosis, cells were exposed for 3 h to 0.1 μg/ml DNA topoisomerase I inhibitor, camptothecin. Quantitative analysis of apoptosis was carried out by flow cytometry. earth sheep chinese zodiacWebNuclear PI-PLC activity in HL-60 cell nuclei after treatment with camptothecin Source publication The pro-apoptotic drug camptothecin stimulates phospholipase D activity and diacylglycerol... ctown reading paWebNational Center for Biotechnology Information earth sheepWebResearch Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells Jennifer Man-Fan. article as: Wan et al., Polysaccharopeptides derived from. properly cited. Research Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase ... earth sheep 1979